Table 1.

Within-trial, post-trial, and lifetime results for US and UK settings (costs in USD and GBP, respectively).

	Period	US			UK
		Exenatide	Placebo	Difference	Exenatide	Placebo	Difference
Therapy costs (study drug + concomitant diabetes medications)	Within-trial	27,675 (2 0 7)	15,446 (1 7 7)	12,229 (2 7 2)*	3724 (25)	1823 (20)	1901 (32)*
	Post-trial	75,464 (1109)	45,972 (6 7 9)	29,492 (4 3 3)*	9796 (1 3 9)	5143 (73)	4653 (66) *
	Lifetime	103,139 (1131)	61,418 (7 0 2)	41,721 (5 1 3)*	13,520 (1 4 1)	6966 (76)	6554 (73) *
Other costs (other medications, visits, hospitalizations and complications)	Within-trial	15,026 (3 1 0)	15,468 (3 1 9)	−442 (4 4 5)	7151 (1 7 1)	7380 (1 6 9)	−229 (2 4 0)
	Post-trial	98,343 (2117)	98,077 (2154)	266 (1 2 4)	33,654 (7 7 5)	33,621 (7 9 2)	33 (47)
	Lifetime	113,369 (2143)	113,545 (2179)	−176 (4 6 2)	40,805 (7 9 4)	41,001 (8 1 0)	−197 (2 4 5)
Total costs	Within-trial	42,701 (4 0 3)	30,913 (3 9 5)	11,787 (5 6 3)*	10,874 (1 7 7)	9203 (1 7 3)	1671 (2 4 8) *
	Post-trial	173,807 (3012)	144,049 (2687)	29,758 (4 4 0)*	43,450 (8 9 4)	38,765 (8 5 5)	4,686 (76) *
	Lifetime	216,508 (3045)	174,963 (2717)	41,545 (7 1 9)*	54,325 (9 1 3)	47,968 (8 7 2)	6357 (2 6 0) *
QALYs	Within-trial	2.674 (0.013)	2.627 (0.012)	0.047 (0.017)*	2.315 (0.012)	2.272 (0.011)	0.043 (0.016) *
	Post-trial	7.410 (0.108)	7.294 (0.107)	0.115 (0.007)*	7.011 (0.099)	6.903 (0.098)	0.108 (0.006) *
	Lifetime	10.084 (0.109)	9.921 (0.108)	0.162 (0.018)*	9.326 (0.100)	9.175 (0.099)	0.151 (0.017) *
Life years	Within-trial	2.937 (0.065)	2.907 (0.065)	0.030 (0.020)	3.013 (0.038)	2.984 (0.039)	0.029 (0.020)
	Post-trial	9.385 (0.138)	9.245 (0.137)	0.139 (0.008)*	8.877 (0.126)	8.746 (0.125)	0.131 (0.007) *
	Lifetime	12.556 (0.139)	12.386 (0.137)	0.170 (0.022)*	11.890 (0.132)	11.730 (0.130)	0.160 (0.021) *
Cost/QALY	Lifetime			259,223			42,589

Values are means (standard errors).

Abbreviations: GBP, British pounds; QALY, quality-adjusted life-year; USD, US dollars.

^*p < 0.05.