Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 8;38(6):110347. doi: 10.1016/j.celrep.2022.110347

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Enhanced gephyrin clustering during iLTP

(A) Representative epifluorescence image of a patched neuron expressing EGFP-gephyrin. Scale bar, 10 μm. The LFS protocol (40-s AP trains at 2 Hz) was delivered by patching the neuron. Please note that the fluorescence scale has been enhanced to visualize small clusters.

(B) Top: Pseudocolor magnification of the dendritic portion framed in (A). Scale bar, 2 μm. Bottom: Timelapse of the gephyrin cluster framed above. The arrow indicates LFS. Scale bar, 1 μm.

(C) EGFP-gephyrin fluorescence increases upon iLTP induction with LFS (arrow) (n = 13, F_4,48 = 21.5, p < 0.001, RM one-way ANOVA followed by Tukey's post-test). Values are expressed as mean ± SEM. ^∗∗∗p < 0.001.