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. 2021 Aug 30;225(4):696–704. doi: 10.1093/infdis/jiab435

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Figure 2. — Associations between pfdhfr genotypes and susceptibilities to PfDHFR inhibitors. (A) Ex vivo susceptibilities to the tested inhibitors are shown for double (51I/108N), triple (51I/108N/59R), and quadruple (51I/108N/59R/164L) mutants with both mixed and pure genotypes. Horizontal bars show medians and interquartile ranges. (B) Ex vivo susceptibilities to the tested inhibitors are shown for isolates with wild-type (I164) or quadruple mutant haplotypes with either mixed (I164L) or pure mutant (164L) sequence at codon 164. Statistical analysis: Mann-Whitney U test: *, P < .05; **, P < .01; ***, P < .001. IC₅₀, half-maximal inhibitory concentration; ns, not significant.