Table 2.
Inhibitor Susceptibilities of Ugandan Isolates With Different Haplotypes
| Median IC50 (nM (n)) | |||||
|---|---|---|---|---|---|
| PfDHFR Haplotypesa | Nb | Pyrimethamine | Cycloguanil | Proguanil | P218 |
| 51I/108N | 22 | 30 200 (22) | 700 (4) | 24 500 (3) | 0.9 (22) |
| 51I/108N/59R | 312 | 41 800 (292) | 1200 (117) | 14 000 (111) | 0.6 (301) |
| 51I/108N/59R/164L | 47 | 101 700 (39) | 2100 (19) | 9200 (17) | 2.6 (44) |
| 51I/108N/59R/164Lmix | 35 | 53 900 (29) | 1500 (16) | 7400 (14) | 1.4 (33) |
| 51I/108N/59R/164Lpure | 12 | 129 500 (10) | 4700 (3) | 17 800 (3) | 5.7 (10) |
| 51I/108N/164L | 2 | 32 200 (2) | - | - | 1.9 (2) |
aIsolates with mixed and pure mutant haplotypes except where separated, as indicated with subscript, into mixed (164Lmix) or pure mutant (164Lpure) at codon 164.
bTotal number of isolates with each haplotype.