Table 5.
Number of pathways enriched with differentially expressed genes (DEGs) that are targets of the 20 miRNAs involved in prostate cancer.
| miRNA | GS 6 | GS 7 (3 + 4) | GS 7 (4 + 3) | GS 8 | GS 9/10 |
|---|---|---|---|---|---|
| miR-10a-5p | 1) Bile secretion (DEGs: 24) |
(DEGs: 27) | (DEGs: 39) | 1) Cell cycle (DEGs: 38) |
1) Cell cycle (DEGs: 38) |
| miR-122-5p | 1) Mucin type O-glycan biosynthesis 2) Glycosphingolipid biosynth - ganglio series (DEGs: 46) |
1) Mucin type O-glycan biosynthesis 2) Glycosphingolipid biosynth - ganglio series (DEGs: 48) |
(DEGs: 64) | (DEGs: 63) | (DEGs: 61) |
| miR-142-3p | (DEGs: 23) | (DEGs: 24) | (DEGs: 32) | (DEGs: 36) | (DEGs: 27) |
| miR-155-5p | (DEGs: 47) | (DEGs: 53) | 1) Melanoma 2) Regulation of actin cytoskeleton 3) Cellular senescence 4) AGE-RAGE signaling pathway in diabetic complications 5) Insulin resistance 6) PI3K-Akt signaling pathway 7) Pancreatic cancer 8) Focal adhesion (DEGs: 68) |
(DEGs: 67) | (DEGs: 65) |
| miR-183-5p | 1) Arrhythmogenic right ventricular cardiomyopathy 2) ECM-receptor interaction 3) Hypertrophic cardiomyopathy 4) Dilated cardiomyopathy (DEGs: 17) |
(DEGs: 19) |
1) Progesterone-mediated oocyte maturation 2) Oocyte meiosis (DEGs: 26) |
1) Progesterone-mediated oocyte maturation 2) Oocyte meiosis (DEGs: 23) |
1) Progesterone-mediated oocyte maturation 2) Oocyte meiosis (DEGs: 27) |
| miR-18a-3p | (DEGs: 25) | (DEGs: 24) | (DEGs: 32) | (DEGs: 29) | (DEGs:33) |
| miR-18a-5p | 1) Focal adhesion (DEGs: 13) |
1) Focal adhesion (DEGs: 13) |
1) Nitrogen metabolism (DEGs: 21) |
1) Nitrogen metabolism (DEGs: 19) |
1) Nitrogen metabolism (DEGs: 23) |
| miR-197-3p | (DEGs: 25) | (DEGs: 30) | (DEGs: 35) | (DEGs: 39) | (DEGs: 38) |
| miR-21-5p | 1) Prostate cancer 2) MicroRNAs in cancer (DEGs): 36 |
1) MicroRNAs in cancer (DEGs: 37) |
1) MicroRNAs in cancer 2) Prostate cancer 3) Hypertrophic cardiomyopathy 4) Dilated cardiomyopathy 5) Endocrine resistance (DEGs: 51) |
1) MicroRNAs in cancer 2) Hypertrophic cardiomyopathy 3) Dilated cardiomyopathy 4) Prostate cancer 5) Bladder cancer 6) Melanoma 7) Hepatitis C 8) Hepatitis B 9) Arrhythmogenic right ventricular cardiomyopathy 10) Endocrine resistance (DEGs: 52) |
1) MicroRNAs in cancer 2) Prostate cancer 3) Hepatitis B 4) Endocrine resistance 5) Melanoma 6) Hepatitis C 7) Small cell lung cancer 8) Bladder cancer 9) Epstein-Barr virus infection 10) Chemical carcinogenesis - receptor activation (DEGs: 57) |
| miR-221-3p | 1) MAPK signaling 2) MicroRNAs in cancer (DEGs:24) |
1) MAPK signaling (DEGs:27) |
(DEGs: 40) |
(DEGs:38) |
(DEGs: 40) |
| miR-25-3p | (DEGS: 32) | 1) Mucin type O-glycan biosynth. (DEGS:25) |
1) Oocyte meiosis 2) Mucin type O-glycan biosynth. 3) Fanconi anemia (DEGs: 44) |
1) Oocyte meiosis 2) Mucin type O-glycan biosynth. 3) Fanconi anemia (DEGS:40) |
1) Oocyte meiosis (DEGs: 49) |
| miR-296-3p | (DEGs: 14) | (DEGs:15) | 1) Viral carcinogenesis 2) Systemic lupus erythematosus 3) Alcoholism 4) Neutrophil extracellular trap formation 5) Central carbon metabolism in cancer 6) Melanoma (DEGs: 21) |
(DEGs:20) | (DEGs: 19) |
| miR-320a | 1) MicroRNAs in cancer 2) Adherens junction (DEGs: 29) |
1) Neutrophil extracellular trap formation (DEGs: 36) |
1) MicroRNAs in cancer 2)Neutrophil extracellular trap formation 3) Viral carcinogenesis 4) Systemic lupus erythematosus 5) Adherens junct. (DEGs:42) |
(DEGs:45) | (DEGs:39) |
| miR-375 | 1) MicroRNAs in cancer (DEGs: 31) |
1) MicroRNAs in cancer (DEGs:34) |
1) MicroRNAs in cancer (DEGs: 39) |
1) MicroRNAs in cancer (DEGs:40) |
1) MicroRNAs in cancer (DEGs:37) |
| miR-423-3p | (DEGs: 10) | (DEGs:13) | 1) Fatty acid metabolism (DEGs:18) |
1) Fatty acid metabolism (DEGs: 16) |
1) Fatty acid metabolism (DEGs: 16) |
| miR-615-3p | 1) ECM-receptor interaction 2) Focal adhesion 3) Viral carcinogenesis (DEGs:38) |
1) Viral carcinogenesis (DEGs:35) |
1) Focal adhesion 2) Viral carcinogenesis 3) ECM-receptor interaction 4) Cell cycle 5) Systemic lupus erythematosus 6) PI3K-Akt signaling (DEGs:64) |
1) Viral carcinogenesis 2) Cell cycle (DEGs:53) |
1) Viral carcinogenesis (DEGs: 59) |
| miR-7-5p | (DEGs: 43) | (DEGs: 35) | (DEGs:51) | (DEGs: 52) | (DEGs: 55) |
| miR-9-5p | 1) Endocrine resistance (DEGs: 28) |
(DEGs: 27) | 1) Endocrine resistance (DEGs: 38) |
(DEGs: 37) |
|
| miR-92a-3p | (DEGs:64) | (DEGs:60) | (DEGs:99) | (DEGs:105) | (DEGs: 104) |
| miR-93-3p |
(DEGs: 9) |
1) ECM-receptor inter. (DEGs: 10) |
1) ECM-receptor inter. (DEGs: 17) |
(DEGs:14) |
(DEGs:15) |