Figure 3.

Upstream analysis by timepoint. Predicted upstream regulators for each experimental timepoint from the core analysis tool of Ingenuity Pathway Analysis (Qiagen, Valencia, CA) are presented. Only upstream regulators with significant predicted activity (|z-score| > 2, P < 0.05) and that exhibit differential expression in the given timepoint comparison (|fold change| > 1.5, FPKM > 1, q-value < 0.05) are represented. The z-score described the degree of activity, the circle size pertains to the number of target genes that appear in the dataset, and the circle outline indicates if the upstream regulator is predicted to be activated (solid) or inhibited (dashed) in the given timepoint.