Table 1.
CTCL Patient Cohort
| Subject ID | Age | Sex | Diagnosis | Ethnicity | Subtype | Therapy | Phototherapy | Status at Sampling Date | TCR Rearrangement by PCR | Positive for Bacillus safensis |
|---|---|---|---|---|---|---|---|---|---|---|
| MF01 | 38 | F | MF | White | Follicular-type CTCL | – | + | Visible lesions (arm) | TCR skin (+) TCR blood (‒) | By ASV (lesional) |
| MF02 | 73 | F | MF | White | CTCL stage IB | – | + | Visible lesions (foot) | TCR skin (+) TCR blood (‒) | – |
| MF03 | 70 | M | MF | White | Follicular-type CTCL | Bexarotene Mechloreth-amine | ‒ | Visible lesions (leg) | TCR skin (+) TCR blood (‒) | By ASV (lesional) |
| MF04 | 62 | F | MF | White | CTCL stage IB | Bexarotene Mechloreth-amine | + | Visible lesions (arm) | TCR skin (+) TCR blood (+) | By ASV (lesional and nonlesional) |
| MF05 | 77 | M | MF | White | CTCL stage IB | – | + | Visible lesions (leg, foot) | TCR skin (NA) TCR blood (‒) | By ASV, culture and FISH |
| MF06 | 65 | M | MF | White | Follicular-type CTCL | Bexarotene Mechloreth-amine | + | Visible lesions (arm) | TCR skin (NA) TCR blood (‒) | By FISH (lesional) |
| MF07 | 62 | F | MF | White | CTCL | – | + | Visible lesions (arm) | TCR skin (+) TCR blood (‒) | By ASV (nonlesional) and FISH (lesional) |
| HD01 | 32 | F | Healthy | White | Negative | No | No | NA | NA | No |
| HD02 | 60 | F | Healthy | White | Negative | No | No | NA | NA | No |
| HD03 | 48 | F | Healthy | White | Negative | No | No | NA | NA | No |
| HD04 | 42 | M | Healthy | Indian | Negative | No | No | NA | NA | No |
| HD05 | 45 | F | Healthy | White | Negative | No | No | NA | NA | No |
Abbreviations: ASV, amplicon sequence variant; CTCL, cutaneous T-cell lymphoma; F, female; HD, healthy donor; ID, identification; M, male; MF, mycosis fungoides; NA, not assessed.
Characteristics of patient and control cohort composed of subject ID, age, sex, diagnosis, ethnicity, subtype, therapy, phototherapy, status at sampling date, and TCR rearrangement by PCR. Mechlorethamine is a topical alkylating drug, and bexarotene is a topical retinoid.