Table 2.
MIC, FICI, and effect of antibiotics in combination.
| Isolate | MIC alone (μg/mL) |
Effect of antibiotics used in combination |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | D | T | V | C + D |
C + V |
D + T |
T + V |
|||||||||
| MIC (μg/mL) |
FICI | MIC (μg/mL) |
FICI | MIC (10) |
FICI | MIC (μg/mL) |
FICI | |||||||||
| C | D | C | V | D | T | T | V | |||||||||
| S48 | 2 | 4 | 0.5 | 4 | 0.125 | 0.25 | 0.062 | 0.125 | 0.5 | 0.19 | 0.016 | 0.125 | 0.25 | 0.125 | 1 | 0.5 |
| J6 | 1 | 2 | 0.5 | 1 | >1 | >2 | NDa | >1 | >1 | ND | 0.125 | 0.062 | 0.19 | >0.5 | >1 | ND |
| NCIM 5021 |
2 | 2 | <0.062 | 2 | 0.062 | 0.5 | 0.28 | 0.125 | 0.5 | 0.31 | 0.016 | 0.031 | 0.26 | >0.062 | >2 | ND |
a
ND-Not determined. Result is interpreted as- FICI ≤0.5 = synergy; FICI >0.5 to 1 = partial synergy, FICI 1 to 2 = additive, FICI 2 to 4 = indifferent and FICI >4 = antagonism. C + D-ciprofloxacin + daptomycin; C + V- ciprofloxacin + vancomycin; D + T-daptomycin + tobramycin; T + V- tobramycin + vancomycin.