Table 1.

Cox regression analysis of overall survival in the different datasets.

Variables	subgroup	Patients	Univariate analysis			Multivariate analysis
			HR	95% CI	P Value	HR	95% CI	P Value
TCGA-COAD Illumina-HiSeq
Age	>65	160	1.262	0.727 - 2.19	0.409	1.805	0.995 - 3.275	0.052
	≤65	95	1			1
Gender	Male	136	1.574	0.905 - 2.738	0.108	1.164	0.657 - 2.062	0.603
	Female	119	1			1
Stage	III-IV	86	3.455	1.991 - 5.997	< 0.001	4.663	2.531 - 8.592	< 0.001
	I-II	169	1			1
TIIsno Score	High	156	4.416	2.142 - 9.103	< 0.001	5.385	2.561 - 11.319	< 0.001
	Low	99	1			1
TCGA-COAD Illumina-GA
Age	>65	80	1.919	0.655 – 5.620	0.235	1.926	0.637 – 5.822	0.246
	≤65	38	1			1
Gender	Male	61	0.589	0.257 - 1.349	0.211	0.729	0.308 - 1.724	0.472
	Female	57	1			1
Stage	III-IV	33	1.914	0.850 - 4.313	0.117	3.324	1.41 - 7.839	0.006
	I-II	85	1			1
TIIsno Score	High	40	11.597	3.932 - 34.202	< 0.001	14.273	4.57 - 44.571	< 0.001
	Low	78	1			1
Xiangya cohort
Age	>65	24	1.213	0.487-3.021	0.678	0.957	0.380-2.406	0.925
	≤65	48	1			1
Gender	Male	35	0.941	0.382-2.317	0.895	0.961	0.389-2.375	0.931
	Female	37	1			1
Stage	III-IV	31	4.843	1.833-12.800	0.001	3.496	1.301-9.391	0.013
	I-II	41	1			1
TIIsno Score	High	45	6.374	1.471-27.62	0.0133	5.223	1.176-23.202	0.03
	Low	27	1			1