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. 2021 Nov 3;13:300–311. doi: 10.1016/j.bioactmat.2021.10.042

Scheme 1.

Scheme 1

Schematic illustration of therapeutic process for fracture healing by using exosomal PD-L1. The Exos with high concentration of PD-L1 is slowly released from the HA/Gel hydrogel, binds to PD-1 on the T cell membrane at fracture site and triggers the immune checkpoint mechanism, and thereby suppressing over-active inflammation and promoting fracture healing.