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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: J Allergy Clin Immunol. 2019 Feb 5;144(1):294–303.e13. doi: 10.1016/j.jaci.2018.11.052

FIG 1.

FIG 1.

NK-cell baseline frequency of most activating receptors in treated HIV-infected patients is elevated. NK cells were defined as CD3−CD45highCD56+ using flow cytometry and gated above fluorescence minus one (FMO) controls for all markers. A-F, Frequency of NK cells expressing DNAM-1, NKp30, NKG2C, CD16, CD11c, and CD2 without stimulation. NKp46 and CD69 incubated in absence of stimulation (G and I) or after 4-hour stimulation with phorbol 12-myristate 13-acetate/ionomycin (H and J). All markers indicate surface expression. Each data point represents a donor; control (n = 29) (red); HEU (n = 23) (green); HIV-infected (n = 25) (purple). All data shown are mean ± S.D. *P < .05, **P < .01, ***P < .001 among 3 cohorts by Kruskal-Wallis and post hoc comparison by Wilcoxon rank-sum test using Bonferroni adjustment.