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. 2022 Feb 9;71(6):1106–1116. doi: 10.1136/gutjnl-2021-326563

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Association of baseline gut bacterial motility and fimbrial gene abundance with neutralising antibody response to CoronaVac and BNT162b2 vaccines at 1 month after second dose of vaccination. (A) Association of baseline gut bacterial motility (based on bacterial relative abundance and bacterial motility phenotype, the Methods section) with neutralising antibody response at 1 month after second dose of vaccination. (B) Association of flagellum-dependent cell motility (GO:0071973) of baseline gut microbiome with neutralising antibody response at 1 month after second dose of vaccination. (C) Association of fimbrial gene abundance (GO:0009289) of baseline gut microbiome with neutralising antibody response at 1 month after second dose of vaccination. CoronaVac (n=37): high-responders, n=16; low responders, n=21. BNT162b2 (n=101) highest tier, n=25; others, n=76. sVNT-10: sVNT level of 10-fold diluted plasma; sVNT-200: sVNT level of 200-fold diluted plasma. Correlation between motility/fimbrial gene abundance and sVNT data was examined using Spearman’s correlation test. Regression lines with 95% CI (grey area) were shown on scatter plots. Comparison between high versus low responder groups/highest tier versus others was made using Wilcoxon’s rank-sum test (two-sided). Elements on boxplots: centre line, median; box limits, upper and lower quartiles; whiskers, 1.5×IQR; points, outliers. sVNT, surrogate virus neutralisation test.