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. 2022 Feb 9;71(6):1106–1116. doi: 10.1136/gutjnl-2021-326563

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Weight status modifies the assocaitions between baseline gut bacterial species and immune response in CoronaVac vaccinees at 1 month after second dose of vaccination. Immune response and ORs to be high responders separated by baseline bacterial abundance within weight strata (A) by Bifidobacterium adolescentis abundance. (B) By Butyricimonas virosa abundance (C) by Adlercreutzia equolifaciens abundance. (D) by Asaccharobacter celatus abundance. sVNT-10: sVNT of 10-fold diluted plasma. Sample size per group was indicated on the figure. Comparisons between subgroups were done using Dunn’s test (one sided) with FDR correction. Model 1: crude model. Model 2: adjusted for age. Reference group: NW with high bacterial abundance. Elements on boxplots: centre line, median; box limits, upper and lower quartiles; whiskers, 1.5×IQR; points, outliers. Each OR was presented as an orange dot with a bar showing the 95% CI. NW, normal weight; FDR, false discovery rate; OWOB, overweight or obese; sVNT, surrogate virus neutralisation test.