Figure EV5. Group‐level PET images without MRI template overlay.

Group‐averaged axial slices of TSPO‐PET (SUV_H scaling) and FDG‐PET (SUV scaling) show microglia activity and glucose metabolism in comparison of Grn ^−/−, Trem2 ^−/−, Double ^−/−, and WT‐type mice. Images represent the raw PET data used for calculation of %‐differences in Figs 1A and 9E.

1. TSPO‐PET images depict increased microglial activity in Grn ^−/− mice, reduced microglial activity in Trem2 ^−/− mice, and similar levels of microglial activity in Double ^−/− and WT mice.
2. FDG‐PET images indicate similar reduction in glucose uptake in Grn ^−/−, Trem2 ^−/−, and Double ^−/− in comparison to WT mice.