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. 2022 Feb 1;13:816640. doi: 10.3389/fimmu.2022.816640

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Copyright © 2022 Hao, Li, Li, Katz, Michalek, Barnum, Pozzo-Miller, Saito, Saido, Wang, Roberson and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pg infection worsens cognitive and behavior impairment in App KI mice. (A) Total distance traveled in open field (OF) tests at 6 months of age. cm, centimeter. (B) Time spent in open arm in elevated zero maze (EZM) tests at 6 months of age. s, second. (C, E) Escape latency in Morris water maze (MWM) tests at 6 (C) and 10 (E) months of age. (D, F) Target annulus crossovers in probe trial tests at 6 (D) and 10 (F) months of age. A-D, n=14/group; E-F, n=21/group (App KI mice), n=7/group (WT mice). Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by two-way ANOVA followed with Tukey correction.