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. 2022 Feb 1;13:816640. doi: 10.3389/fimmu.2022.816640

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Copyright © 2022 Hao, Li, Li, Katz, Michalek, Barnum, Pozzo-Miller, Saito, Saido, Wang, Roberson and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pg activates microglia in App KI mice and co-localize with complement C1q. Brain sections from 6-month-old non-infected and Pg-infected App KI mice were immune-stained with antibodies against IBA1and C1qa. (A) Representative Z-stack images of brain sections depicting the spatial association between microglia (red) and C1qa (green). (B) Quantification of IBA1⁺ cells in the hippocampus and cortex regions. n=6-7 mice/group. (C) Percentage of IBA1⁺C1qa⁺ microglia in non-infected and Pg-infected App KI mice. Five representative micrographs of the cortex and hippocampus regions from each mouse were analyzed (n=5-7 mice/group). Data are expressed as mean ± SEM. *P < 0.05, ***P < 0.001, ****P < 0.0001 by unpaired Students t-test.