Table 3.

Association between toenail Se concentration and risk of death in high grade tumors (N=254)

Se (μg/g)	No. Deaths	Crude HR (95% CI)	(n=254) Multivariate HR (95% CI)*	p-value	(n=210) Multivariate HR (95% CI)**	p-value
<0.742	24	Ref	Ref	----	Ref	----
0.743–0.890	70	1.22 (0.77, 1.94)	1.17 (0.73, 1.87)	0.523	0.98 (0.59, 1.62)	0.92
0.891–1.037	59	1.25 (0.78, 2.01)	1.38 (0.85, 2.25)	0.20	1.18 (0.69, 2.00)	0.54
>1.037	21	1.07 (0.59, 1.92)	1.08 (0.59, 1.98)	0.81	0.99 (0.52, 1.88)	0.97
Trend			1.06 (0.89, 1.26)	0.50	1.04 (0.86, 1.25)	0.70

^*Model adjusted for age (5 year groups), gender, and histology (GBM, high grade astrocytoma, high grade pure/mixed oligodendroglioma).

^**Restricted to cases with KPS data. Model adjusted for age (5 year groups), gender, histology (GBM, high grade astrocytoma, high grade pure/mixed oligodendroglioma), and KPS group