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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Cell Rep. 2021 Oct 12;37(2):109813. doi: 10.1016/j.celrep.2021.109813

Figure 3. Male and female MafAS64F/+ islet cells regulate a common and distinct set of genes associated with Ca2+ and K+ channel activity.

Figure 3.

(A) The Venn diagram illustrates the total number of RNA-seq-identified genes differentially up- or down-regulated between 5-week-old WT and MafAS64F/+ islets.

(B) Gene Ontology (GO): molecular function analysis (p < 0.05) of the 391 genes commonly up- or down-regulated in MafAS64F/+ (Het) islets revealed alterations in multiple ion channel activity pathways.

(C) Heatmaps showing channel gene expression changes common between male and female MafAS64F/+ islets.

(D) Heatmap of Ca2+ signaling pathway genes uniquely increased in male MafAS64F/+ islets identified by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis (also see Figure 5A). False discovery rate (FDR) < 0.05.