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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Cell Rep. 2021 Oct 12;37(2):109813. doi: 10.1016/j.celrep.2021.109813

Figure 5. Male MafAS64F/+ islets display increased expression of aging, DDR, SASP, and cytokine pathway gene signatures.

Figure 5.

(A) KEGG analysis of the 1,842 genes specifically upregulated in 5-week-old male MafAS64F/+ (Het) islets.

(B–E) Heatmaps reveal male MafAS64F/+ islets have increased expression of pathway genes associated with (B) aging, (C) DDR, (D) SASP, and (E) cytokine-cytokine receptor interactions. FDR < 0.05.

(F) qRT-PCR confirmation of pathway gene changes in 5-week-old male MafAS64F/+ islets (solid bars). Gene expression was unchanged at 4-week-old male MafAS64F/+ islets, with the exception of Cdkn1a (p21) upregulation (hash-marked bars). Two-tailed Student t test; *p < 0.05; **p < 0.01.