KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Guinea pig anti-Insulin	Thermo Fisher	Cat#PA1 26938; RRID:AB_794668
Mouse anti-Glucagon	Sigma	Cat#G2654; RRID:AB_259852
Mouse anti-Ki67	BD Biosciences	Cat#550609; RRID:AB_393778
DAPI Fluoromount-G mounting medium	SouthernBiotech	Cat#0100-20
Rabbit anti-MAFA	Cell Signaling	Cat#79737; RRID:AB_2799938
Goat anti-PDX-1	Chris Wright, Vanderbilt	N/A
Rabbit anti-UCN3	Phoenix	Cat#H-019-028; RRID:AB_2889826
Goat anti-P21 (for cells)	Santa Cruz	Cat#sc-397G; RRID:AB_632127
Rat anti-P21 (for tissue sections)	Abcam	Cat#ab107099; RRID:AB_10891759
Rabbit anti-53BP1	Bethyl	Cat#A300-272A; RRID:AB_185520
Rabbit anti-gH2AX	Abcam	Cat#ab81299; RRID:AB_1640564
Rabbit anti-LaminB1	Abcam	Cat#16048; RRID:AB_443298
Bacterial and virus strains
Lentivirus: MAFAWT-pCDH-EF1-MCS-IRES-GopGFP	Modified for this paper from System Biosciences	Cat#CD521A-1
Lentivirus: MAFAS64F-pCDH-EF1-MCS-IRES-GopGFP	Modified for this paper from System Biosciences	Cat#CD521A-1
Chemicals, peptides, and recombinant proteins
Fura-2 AM	Life Technologies	Cat#F1221
Critical commercial assays
Cell Death Detection Kit	Roche	Cat#11684795910
Senescence β-Galactosidase Staining Kit	Cell Signaling	Cat#9860
Glycogen Assay Kit	Cayman Chemicals	Cat#700480
Deposited data
Raw and analyzed data	This paper	GEO:GSE183561
Experimental models: Cell lines
Human: EndoC-βH2 Cells	Scharfmann et al., 2014	N/A
Experimental models: Organisms/strains
Mouse: MafAS64F/+	This paper	N/A
Oligonucleotides
Primers for mouse and human see Table S1	This paper	N/A
Software and algorithms
Genialis visual informatics platform: BBDuk, START aligner, featureCounts	https://www.genialis.com	N/A
DESeq2	Love et al., 2014	N/A
ImageJ	https://imagej.nih.gov/ij/	N/A
ImageScope Software	Aperio Technologies	N/A