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. 2021 Nov 3;66(2):206–222. doi: 10.1165/rcmb.2021-0292OC

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Copyright © 2022 by the American Thoracic Society

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0. For commercial usage and reprints, please e-mail Diane Gern (dgern@thoracic.org).

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Figure 5. — Local IFN response is independent of age and virus. (A) Heatmap of z-score normalized expression (CPM) of 222 type I and II IFN response genes. Hierarchical clustering on genes (rows) did not identify distinct clusters. Samples within SARS-CoV-2, IV, and RSV groups are ordered by ascending viral reads for SARS-CoV-2, IV, or RSV, respectively. (B) Average normalized expression of IFN response genes (combined Hallmark pathway lists for IFN-α and IFN-γ response) by participant group. (Adjusted P value < 0.05 is considered statistically significant, Kruskal-Wallis test with Benjamini-Hochberg FDR correction). Log-transformed CPM counts are shown. (C) Scatter plot of correlation between age (years) and average IFN response reads. Log-transformed CPM counts are shown. Pearson correlation coefficient (r) and P value are shown. (D) Scatter plot of correlation between average IFN response reads (log₂CPM) and SARS-CoV-2, RSV, or IV viral reads, respectively. Pearson r values and P values are shown. (E) Heatmap of z-score normalized expression (CPM) for 19 secreted type I, II, and III IFNs.

Figure 5. — Local IFN response is independent of age and virus. (A) Heatmap of z-score normalized expression (CPM) of 222 type I and II IFN response genes. Hierarchical clustering on genes (rows) did not identify distinct clusters. Samples within SARS-CoV-2, IV, and RSV groups are ordered by ascending viral reads for SARS-CoV-2, IV, or RSV, respectively. (B) Average normalized expression of IFN response genes (combined Hallmark pathway lists for IFN-α and IFN-γ response) by participant group. (Adjusted P value < 0.05 is considered statistically significant, Kruskal-Wallis test with Benjamini-Hochberg FDR correction). Log-transformed CPM counts are shown. (C) Scatter plot of correlation between age (years) and average IFN response reads. Log-transformed CPM counts are shown. Pearson correlation coefficient (r) and P value are shown. (D) Scatter plot of correlation between average IFN response reads (log₂CPM) and SARS-CoV-2, RSV, or IV viral reads, respectively. Pearson r values and P values are shown. (E) Heatmap of z-score normalized expression (CPM) for 19 secreted type I, II, and III IFNs.