Figure 7.

MPO/HOCl facilitated apoptosis and ferroptosis and exerted motor performance impaired in hSOD1^G93A mice. (a) Immunoblots of apoptosis- and ferroptosis-related proteins in hSOD1^WT and hSOD1^G93A mice, with or without treatment of ABAH in male (left) and female (right) mice. (b) The plasma MDA levels of male (left) and female (right) mice. (c) The motor performance of mice (left: male; right: female). Quantified graphs were shown as means and SEM. ^∗P < 0.05,  ^∗∗P < 0.01, and^∗∗∗P < 0.001. The significant difference in two datasets was analyzed by Student's t-test.