Table 2.
Effect of lnBMI and rs373863828 on type 2 diabetes and fasting glucose in the meta-analysis, stratified by obesity status and genotype
| Stratified by obesity status | |||||
| Meta-analysis: lnBMI | Meta-analysis: rs373863828 | ||||
| Dependent variable: type 2 diabetes | |||||
| Stratum* | n | OR (95% CI) | P value | OR (95% CI) | P value |
| Without obesity | 2316 (244 cases) | 7.77 (1.48 to 40.78) | 0.015 | 0.59 (0.43 to 0.81) | 9.80×10−4 |
| With obesity | 4765 (1015 cases) | 5.01 (2.98 to 8.42) | 1.12×10−9 | 0.67 (0.58 to 0.77) | 1.09×10−8 |
| Dependent variable: natural log-transformed fasting glucose | |||||
| Stratum* | n | β (SE) | P value | β (SE) | P value |
| Without obesity | 1616 | 0.213 (0.055) | 9.53×10−5 | −0.036 (0.009) | 4.57×10−5 |
| With obesity | 2916 | 0.162 (0.036) | 5.63×10−6 | −0.029 (0.008) | 1.66×10−4 |
| Stratified by genotype | |||
| |
Meta-analysis: lnBMI | ||
| Dependent variable: type 2 diabetes | |||
| Stratum | n | OR (95% CI) | P value |
| GG | 4111 (824 cases) | 6.37 (4.03 to 10.05) | 1.88×10−15 |
| GA | 2547 (389 cases) | 7.049 (2.85 to 17.47) | 2.46×10−5 |
| AA | 232 (22 cases) | 1.774 (0.19 to 16.93) | 0.619 |
| Dependent variable: natural log-transformed fasting glucose | |||
| Stratum | n | β (SE) | P value |
| GG | 2442 | 0.245 (0.027) | 3.12×10−20 |
| GA | 1759 | 0.214 (0.034) | 1.89×10−10 |
| AA | 331 | 0.161 (0.062) | 0.001 |
*Without obesity: BMI ≤30 kg/m2; with obesity: BMI >30 kg/m2.
BMI, body mass index; lnBMI, log-transformed body mass index.