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. 2022 Feb 14;10:24. doi: 10.1186/s40478-022-01325-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — a MRI sagittal plane, T1 sequence without gadolinium injection showing a hypointense right temporal tumor. b MRI axial plane, T2 sequence showing a hyperintense right temporal tumor. c MRI axial plane, apparent diffusion coefficient (ADC) values showing a low ADC in the right temporal tumor. d, e Hematoxylin and Eosin (H&E) stain × 200 (d) and × 400 (e) showing a hypercellular tumor with pleomorphic cells harboring numerous mitoses. f SMARCE1 immunohistochemistry, × 400, showing a lack of expression in tumor cells with positive cells in a vessel as an internal control. g BAF47 immunohistochemistry, × 400, showing a maintained nuclear expression in tumor cells. h olig2 immunohistochemistry, × 400, showing a diffuse nuclear expression in tumor cells. i α-smooth actin immunohistochemistry, × 400, showing a cytoplasmic expression in tumor cells. j EMA immunohistochemistry, × 400, showing a patchy expression in tumor cells. k Copy number variation profile showing a complex profile. l Details of SMARCE1 and TP53 pathogenic variants. m UMAP showing the close localization of the tumor with ATRT