Table 4.
List of parameters used in within-host modeling.
| Parameter definition | Range of values | References |
|---|---|---|
| Initial value for target cells (cell ml−1) | [2 × 104,1 × 108] | [97], [98], [99], [103], [108], [109] |
| Initial value for free viral particles upon infection (cell ml−1) | [1, 357] | [22], [97], [132] |
| Initial number of infected cells (cell ml−1) | [0,3 × 10−4] | [101], [103], [108], [109] |
| Target cell production rate (cell ml−1 day−1) | [300,1.4 × 106] | [22], [97], [101], [102], [106], [107], [108], [110] |
| Death rate of susceptible target cells (day−1) | [0.03, 0.333] | [97], [101], [102], [105], [109], [110] |
| Infection rate of susceptible target cells (viral particle−1 day−1) | [5 × 10−11,1 × 10−8] | [22], [94], [98], [103], [106] |
| Death rate of infected target cells (day−1) | [0.14,3.5] | [22], [95], [102], [104], [105], [106], [108], [110] |
| Removal rate of infected cells per immune cell (day−1) | [0.001,0.05] | [95], [102], [105], [110] |
| Viral replication factor | [20, 10000] | [22], [98], [103], [105], [106], [108] |
| Virus clearance rate (day−1) | [0.03, 9.562] | [22], [93], [96], [98], [99], [102], [103], [105], [106], [108], [126] |
| Proportionality constant relating viral load to transmission rate | [0,0.03] | [100] |
| Antibody/Immune cells production rate (day−1) | [0.0265, 13.89] | [22], [94], [95], [98], [102], [105], [109] |
| Antibody decay rate (day−1) | [1/365, 0.07] | [102], [104], [105], [108], [170] |
| Incubation period (day) | 5.9 | [103] |
| Production rate of virions per infected cell (day−1) | [1 × 104,1.1 × 105] | [103], [110] |
| Recruitment rate of Natural Killer NK cells (day−1) | [0.52,0.0624] | [95], [109] |
| Killing rate of Natural Killer NK cells (day−1) | [5.74 × 10−4,2 × 10−3] | [98], [102], [103], [109] |
| Recruitment rate of T cells ((cell ml−1)−1 day−1) | [4.5 × 10−7,3 × 10−5] | [98], [103], [109] |
| Killing rate of T cells (day−1) | [1 × 10−6,1.2 × 10−4] | [98], [103], [109] |
| Killing rate of infected target cells by Natural Killer NK cells (day−1) | [0.002,0.077] | [98], [102] |
| Production rate of interferon INF (day−1) | 0.8 | [102] |
| Decay rate of interferon INF (day−1) | [0.7,1.6639] | [98], [102] |
| Cross-reactive antibody activation rate | 0.4 | [96] |
| Specific antibody activation rate | 0.5 | [96] |
| Fraction of infected cells producing immature virus | (0,0.9) | [98] |