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. 2022 Feb 15;20:80. doi: 10.1186/s12951-022-01287-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — In vitro and in vivo homologous-targeted effects of CHINPs and biodistribution. A Flow cytometric profiles of 4T1 cells treated with HINPs and CHINPs and B the corresponding mean fluorescence intensity. C CLSM images of different cells treated with HINPs, CHINPs. Scale bar: 20 μm. D Flow cytometric profiles of different cells treated with HINPs, CHINPs and F the corresponding cellular uptake. E In vivo distribution of HINPs and CHINPs in 4T1 tumor-bearing Balb/c mice examined by fluorescence imaging at different time points and Ex vivo tissue distribution in the main organs: heart, liver, spleen, lung, kidney, and tumor. G The corresponding mean fluorescence intensity of tumor by in vivo fluorescence imaging. H Quantitative biodistribution of CHINPs in Balb/c mice determined by ICP-MS. Data shown are mean ± SD (n = 3). Statistical differences determined by one-way ANOVA; *p < 0.05, **p < 0.01