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. 2022 Feb 14;14:23. doi: 10.1186/s13148-022-01243-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — FEM-modules derived from TCGA EAC cohort. Barplot lists the significant FEM-modules labeled by the seed-gene with the number of genes in each module given in brackets. Length of bars indicate the number of genes within the module that are significantly differentially methylated (DM), significantly differentially expressed (DR), jointly differentially methylated and differentially expressed (DM & DR) and the subset of these that exhibit anticorrelation between promoter DNAm and gene-expression. We display 3 modules defined by seed-genes, CTNND2, CCL20 and NCAM1. The node color indicates differential DNAm, with the border color indicating differential expression, as specified in the color-bars