Fig. 2.

Impacts of circ_IRAK3 inhibition on malignant behaviors of BC cells. A–L HCC70 and MDA-MB-231 cells were transfected with si-NC or si-circ_IRAK3. A, B QRT-PCR was employed to assess the levels of circ_IRAK3 and IRAK3 mRNA in HCC70 and MDA-MB-231 cells. C–G The cell cycle progression, colony formation, and proliferation were analyzed by flow cytometry, colony formation, or MTT assays. H–J The migration, invasion, and apoptosis of HCC70 and MDA-MB-231 cells were assessed by transwell or flow cytometry assays. K, L The levels of Bax, Cleaved PARP, and Bcl-2 in HCC70 and MDA-MB-231 cells were examined by western blotting. *P  < 0.05