Figure 4.

Log ratio of desmoplastic to inflamed stroma area in rectal cancer. A, Box and whisker plot showing log ratio of desmoplastic to inflamed stroma determined by deep neural network (DNN) (D:I) for stromal area in 140 rectal cancers. The median log D:I was 1.01 in 26 patients who developed recurrence and 0.74 in 114 who remained disease‐free. The log D:I was significantly higher in the recurrence group, P = 0.00067. B, Receiver operating characteristic (ROC) curve assessing log D:I as predictor of recurrence. Using the Youden criterion, the optimal cut‐off is log D:I = 0.73, with area under the curve (AUC) = 0.71, C, disease‐free survival by D:I, with high D:I defined as ≥5.41, the cut‐off value on the ROC curve. [Colour figure can be viewed at wileyonlinelibrary.com]