Table 2.
Subgroup analysis of metabolic syndrome (MetS) for the highest vs. lowest dietary iron level category.
Stratification | Number of studies | Pooled RR | 95% CI | P- value | Heterogeneity |
---|---|---|---|---|---|
All studies | 7 | 1.27 | 1.12, 1.44 | P < 0.001 | P = 0.01; I2 = 44% |
Study design | |||||
Cross-sectional | 5 | 1.31 | 1.13, 1.52 | P < 0.001 | P = 0.12; I2 = 45% |
Cohort | 2 | 1.34 | 0.72, 2.47 | P = 0.35 | P = 0.10; I2 = 62% |
Race | |||||
Asian | 4 | 1.44 | 1.13, 1.83 | P = 0.003 | P = 0.10; I2 = 53% |
American | 3 | 1.04 | 0.81, 1.32 | P = 0.77 | P = 0.69; I2 = 0% |
Diagnostic criteria of MetS | |||||
NCEP ATP III | 4 | 1.59 | 1.30, 1.93 | P < 0.001 | P = 0.75; I2 = 0% |
Other | 3 | 1.08 | 0.91, 1.27 | P = 0.37 | P = 0.62; I2 = 0% |
Sample size | |||||
<1,000 | 2 | 0.94 | 0.53, 1.66 | P = 0.83 | P = 0.43; I2 = 0% |
>1,000 | 5 | 1.34 | 1.09, 1.65 | P = 0.006 | P = 0.06; I2 = 56% |
Exposure assessment | |||||
FFQ | 1 | 2.04 | 0.97, 4.29 | / | / |
24 h or 3 days recall | 6 | 1.25 | 1.10, 1.42 | P < 0.001 | P = 0.10; I2 = 45% |
Type of iron | |||||
Heme iron | 5 | 0.98 | 0.79, 1.22 | P = 0.88 | P = 0.04; I2 = 61% |
Non-heme iron | 5 | 1.25 | 1.08, 1.46 | P = 0.004 | P = 0.18; I2 = 36% |