TABLE 1.

Nuclear structures containing PML.

PML structure	Description	Conditions/Stimuli	Localization	Key components	Diagnostic criteria	References
PML NB	PML nuclear bodies	Normal cells	4–30 bodies per cell	SUMO, SP100, DAXX	SUMO, SP100, DAXX	Song et al. (2004), Cheng and Kao (2012), Banani et al. (2016), Hoischen et al. (2018), Corpet et al. (2020)
LAPS	Lipid-associated PML structures	Excess oleate	nLD	CCTα, Lipin1, DAG	Visualized with lipid dyes	Ohsaki et al. (2016), Lee et al. (2020)
APB	ALT-associated PML bodies	ALT-positive cancer cells	Telomere- associated PML bodies	SUMO, SP100, DAXX, BTR complex, TRF2, telomeric DNA	Co-localization withTRF2 in tert-negative cells	Chung et al. (2012), Loe et al. (2020)
MAPP	Mitotic accumulation of PML proteinsl	Mitosis	Endosome- associated	PML protein aggregates	Co-localization with EEA1, TfR	Dellaire et al. (2006b); Palibrk et al. (2014)
PML patches	Nuclear lamin- associated patches/threads	Hutchinson-Gilford progeria cells; senescent cells	PML-II on nuclear lamina, type-1 NR	SUMO	Reduced associated with DNA repair proteins (yH2AX, RPA32, MRE11)	Wang et al. (2020)
				DAXX
				Progerin
Nucleolar caps	Senescence-associated PML-I caps	Senescent cells	surrounding nucleolar fragments and blebs	SUMO, DAXX, SP100,B23, DHX9,FBL	Co-localization with nucleolus-fibrillar center	Condemine et al. (2007), Imrichova et al. (2019)
PML clastosomes	PolyQ-associated PML rings at nuclear protein inclusions	Misfolded polyQ proteins, UV	Enlarged nuclear ring	CRAG	Co-localization with ubiqutitin-positive inclusions; SUMO	Qin et al. (2006), Guo et al. (2014), Janer et al. (2006)
				RNF4
				SUMO
				PML