Table 3.
Meta-regression and subgroup analyses for the potential sources of heterogeneity.
| Variables | Endpoint | No. of comparisons | Coeff./OR/WMD WMD | 95% CI | P-value | ||
|---|---|---|---|---|---|---|---|
| Univariate | Coeff. | Adjusted R2 | |||||
| Age (years) | POD (Ln) | 6 | 0.09 | 0.02 ~ 016 | 0.03 | 0.99 | |
| POCD (Ln) | 5 | 0.13 | 0.01 ~ 0.26 | 0.04 | 0.93 | ||
| BMI | POD (Ln) | 4 | 0.53 | −0.01 ~ 1.07 | 0.05 | 0.97 | |
| CHD (%) | POD (Ln) | 6 | −0.17 | −0.30 ~−0.04 | 0.02 | 0.92 | |
| DM (%) | ICU stay | 7 | 0.03 | −0.003 ~ 0.07 | 0.07 | 0.65 | |
| CVA (%) | ICU stay | 5 | 0.11 | 0.04 ~ 0.18 | 0.02 | 1.00 | |
| COPD (%) | ICU stay | 5 | −0.10 | −0.23 ~ 0.31 | 0.09 | 1.00 | |
| Subgroup | I 2 | PDifference value | |||||
| OR | |||||||
| 1. Age (years) | POD | 6 | 0.01 | ||||
| ≥71.0 | 2 | 0.39 | 0.04 ~ 3.74 | 0.42 | 77.1% | ||
| <71.0 | 4 | 0.22 | 0.05 ~ 1.00 | 0.05 | 81.50% | ||
| 2. Age (years) | POCD | 5 | 0.001 | ||||
| ≥63.0 | 2 | 0.89 | 0.55 ~ 1.44 | 0.64 | 0.00% | ||
| <63.0 | 3 | 0.17 | 0.05 ~ 0.59 | 0.01 | 70.8% | ||
| 3.BMI | POD | 4 | <0.001 | ||||
| ≥25.0 | 3 | 0.41 | 0.10 ~ 1.59 | 0.20 | 65.7% | ||
| <25.0 | 1 | 0.02 | 0.004 ~ 0.09 | <0.001 | % | ||
| 4. CHD | POD | 6 | <0.001 | ||||
| ≥20.0% | 5 | 0.59 | 0.32 ~ 1.07 | 0.08 | 34.3% | ||
| <20.0% | 1 | 0.02 | 0.004 ~ 0.09 | <0.001 | % | ||
| WMD | |||||||
| 5. DM | ICU stay | 7 | <0.001 | ||||
| ≥25.0% | 5 | −0.12 | −0.41 ~ 0.17 | 0.42 | 56.7% | ||
| <25.0% | 2 | −0.72 | −0.98 ~−0.47 | <0.001 | 0.0% | ||
| 6. CVA | ICU stay | 5 | <0.001 | ||||
| ≥10.0% | 3 | −0.05 | −0.30 ~ 0.19 | 0.66 | 41.4% | ||
| <10.0% | 2 | −0.72 | −0.95 ~−0.99 | <0.001 | 0.0% | ||
| 7. COPD | ICU stay | 5 | 0.06 | ||||
| ≥16.0% | 2 | −0.56 | −1.09 ~−0.04 | 0.04 | 0.0% | ||
| <16.0% | 3 | −0.05 | −0.30 ~−0.19 | 0.66 | 41.4% |
POD, postoperative delirium; POCD, postoperative cognitive decline; ICU stay, intensive care unit stay; BMI, body mass index; CHD, congenital heart disease; DM, diabetes mellitus; CVA, cardiovascular accident; COPD, chronic obstructive pulmonary disease; Coeff., coefficient; OR, odds ratio; WMD, weighted mean difference; CI, confidence Interval.