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. 2022 Feb 1;9:809668. doi: 10.3389/fcell.2021.809668

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Copyright © 2022 Zhang, Ma, Yang, Fan, Tian, Niu, Yan, Zheng and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell fusion and cancer progression. Cell fusion is a two-edge sword that occurs during the development and progression of cancer. The exchange of DNA between cancer cells and non-cancer cells via cell fusion may result in a different fate of cancer cells. Metastatic potential genes from macrophages (or cancer cells) to cancer cells may enhance the migration and invasive abilities. Tumor suppressor genes exchanged from normal cells to cancer cells may inhibit the malignant progression of cancer cells.