TABLE 3.

Allocation of animals per group and investigation

Analyses	Animal (n = 12/group)
	1	2	3	4	5	6	7	8	9	10	11	12
TKA surgery + bacterial inoculation (day 0)	X	X	X	X	X	X	X	X	X	X	X	X
Serum levels of vancomycin (day 0)	X	X	X	X	X	X
General status (days 0, 1, 4, 7, 14)	X	X	X	X	X	X	X	X	X	X	X	X
Incision examination (days 0, 1, 4, 7, 14)	X	X	X	X	X	X	X	X	X	X	X	X
X-ray (day 14)	X	X	X	X	X	X
Micro-CT (day 14)	X	X	X	X	X
Knee histology (day 14)	X	X	X	X	X
Prosthesis SEM (day 14)	X	X	X	X	X
Microbiology (day 14)						X	X	X	X	X	X	X
Liver or kidney histology (day 14)	X	X	X	X	X	X	X	X	X	X	X	X
Serum ALT, AST, or Cr analysis (day 14)	X	X	X	X	X	X	X	X	X	X	X	X