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. 2022 Feb 15;66(2):e02022-21. doi: 10.1128/aac.02022-21

FIG 2.

FIG 2

MEDI3902 prophylaxis improved survival and reduced bacterial burden in a rabbit model of ventilator-associated pneumonia. Kaplan-Meier survival curves (A and E), LW/BW ratios (B and F), log10CFU per milliliter of blood (C and G), and log10CFU per organ (D and H) for rabbits treated intravenously with 15 mg/kg MEDI3902 or 15 mg/kg c-IgG 24 h before infection with P. aeruginosa strain 6077 and monitored for 36 h (study 1) (A to D) or 60 h (study 2) (E to H) were compared. Bars indicate the medians for all treatment groups. The LW/BW ratio and log10CFU per organ for rabbits pretreated with MEDI3902 were compared to values for rabbits pretreated with c-IgG by nonparametric Mann-Whitney U test.