Figure 6.

Effects of CIH on the serum metabolome. (A) The PCA plot of metabolites generated by using the metabolite intensity from the NM (n = 8), CIH (n = 10), NM+HFD (n = 8), and CIH+HFD (n = 10) groups. (B) Volcano plots of metabolites with FDR < 0.05 and fold changes of > 4/3 or < 3/4 when comparing NM vs CIH, or comparing NM+HFD vs CIH+HFD. (C) Enrichment of activated pathways induced by alterations of metabolites in NM, CIH, NM+HFD and CIH+HFD groups. (D–S) The abundance of metabolite pathways from the NM, CIH, NM+HFD and CIH+HFD groups. Data are expressed as mean ± SEM. Group differences were assessed by using the Mann‐Whitney U test. ^*P < 0.05 when comparing NM vs CIH, or NM+HFD vs CIH+HFD, ^#P < 0.05 when comparing NM vs NM+HFD.