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. 2022 Feb 15;130(2):027008. doi: 10.1289/EHP9297

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figure 5A is a set of three heatmaps titled Median, Quadratic Entropy, and Earth Mover’s Distance, plotting Nickel (chloride), cobalt (chloride), potassium chromate, mercuric chloride, zinc (chloride), Cadmium (chloride), Lead (nitrate), 1,2,3-trichlorobenzene, 4,6-dinitro-o-cresol, Organochlorine pesticide, Cresol, para, Dicofol, 2,4-dinitrotoluene, 2,4-dinitrophenol, methoxychlor, endosulfan, benzidine, Dichlorodiphenyldichloroethylene, acenaphthene, trifluralin, benzo(b)fluoranthene, parathion, 2,4,5-trichlorophenol, azinphos-methyl, ethion, 2,4,6-trichlorophenol, di(2-ethylhexyl)phthalate, Chlorpyrifos, di-n-butyl phthalate, pentachlorophenol, heptachlor epoxide, diazinon, endrin, disulfoton, hexachlorocyclohexane, gamma-, heptachlor, aldrin, dieldrin, Dichlorodiphenyldichloroethylene, fluoranthene, naphthalene, and benzo(a)anthracene (y-axis) across treatment ratio, ranging as 10 picomolar, 1 nanomolar, 100 nanomolar, 1 micromolar, 5 micromolar, and 10 micromolar (x-axis), respectively. A scale depicting Median is ranging from 0.32 to 1.31 in increments 0.99. A scale depicting Quadratic Entropy is ranging from 0.40 to 1.18 in increments of 0.78. A scale depicting Earth Mover’s Distance is ranging from 0.06 to 51.4 in increments of 51.34. Figure 5B is a set of four line graphs tiled Polycyclic aromatic hydrocarbons, Metals, Pesticides, and para-Cresol, plotting fold median, ranging from 0.0 to 1.5 in increments of 0.5 (y-axis) across concentration (log molar), ranging from negative 12 to negative 4 in increments of 2 (x-axis) for Benz(a)anthr, Benz(b)flour, mercury, Cadmium, Chromium, Dichlorodiphenyldichloroethylene, Azinphos, and Disulfoton. Figure 5C is a dot graph, plotting log activity concentration, 50 percent, ranging from negative 8 to 0 in increments of 2 (y-axis) across Benz(a)anthracene, naphthalene, fluoranthene, Dichlorodiphenyldichloroethylene, dieldrin, aldrin, heptachlor, lindane, disulfoton, endrin, diazinon, epoxyheptachlor, pentachlorophenol, dibutyl phthalate, chlorpyrifos, di(2-ehylhexyl) phthalate, 246-trichlorophenol, parathion, benzo(b)fluoranthene, trifluralin, acenaphthene, 2,2-bis(p-chlorophenyl)ethane, benzidine, endosulfan, methoxychlor, 24-dinitrophenol, 24-dinitrotoluene, dicofol, para-cresol, Organochlorine pesticide, 2-methyl-46-dinitrophenol, 123-trichlorobenzene, and mercuric chloride (x-axis). — Evaluation of 42 chemicals from the ATSDR list for estrogenic activity by single cell ER analysis. (A) Heat maps for the three indicated descriptors (fold median of DMSO control, QE, and EMD, $lowercase italic n greater than 3$ independent biological replicates) after treatment of MCF-7 cells for 24 h with the ATSDR 42 set of compounds. (B) Fold median ER dose response data for three classes of chemicals, plus para-cresol, that where hits from the ATSDR 42 set. (C) $log of activity concentration, 50 percent$ (activity concentration 50%) comparison between ER descriptors (fold median, triangles; QE, diamonds; EMD, squares) and ToxCast assays (black dots) for the ATSDR 42 chemicals. Summary data are found in Excel Tables S13-S15. Note: ATSDR, Agency for Toxic Substances and Disease Registry; ER, estrogen $receptor-alpha$ ; EMD, earth mover’s distance; PAH, polycyclic aromatic hydrocarbons; QE, quadratic entropy.