TABLE 2.
Distribution of gepotidacin and comparator MICs against Gram-negative and Gram-positive anaerobic isolates
| Organism group and antimicrobial agent | No. (cumulative %) of isolates with gepotidacin MIC of: |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.015 μg/mL | 0.03 μg/mL | 0.06 μg/mL | 0.12 μg/mL | 0.25 μg/mL | 0.5 μg/mL | 1 μg/mL | 2 μg/mL | 4 μg/mL | 8 μg/mL | 16 μg/mL | 32 μg/mL | >32 μg/mL | |
| All Gram negativea (333 isolates) | |||||||||||||
| Gepotidacin | 17 (5.1) | 9 (7.8) | 22 (14.4) | 33 (24.3) | 40 (36.3) | 67 (56.5) | 75 (79.0) | 33 (88.9) | 25 (96.4) | 6 (98.2) | 3 (99.1) | 1 (99.4) | 2 (100) |
| Ceftriaxone | 169 (50.8) | 26 (58.6) | 29 (67.3) | 109 (100) | |||||||||
| Clindamycin | 129 (38.7) | 47 (52.9) | 41 (65.2) | 27 (73.3) | 18 (78.7) | 71 (100) | |||||||
| Imipenem | 39 (11.7) | 27 (19.8) | 62 (38.4) | 67 (58.6) | 70 (79.6) | 37 (90.7) | 22 (97.3) | 5 (98.8) | 1 (99.1) | 3 (100) | |||
| Metronidazole | 129 (38.7) | 43 (51.7) | 88 (78.1) | 33 (88.0) | 22 (94.6) | 12 (98.2) | 1 (98.5) | 5 (100) | |||||
| Moxifloxacin | 8 (2.4) | 21 (8.7) | 88 (35.1) | 71 (56.5) | 49 (71.2) | 23 (78.1) | 36 (88.9) | 37 (100) | |||||
| Piperacillin-tazobactam | 82 (24.6) | 33 (34.5) | 44 (47.7) | 19 (53.5) | 30 (62.5) | 22 (69.1) | 20 (75.1) | 37 (86.2) | 17 (91.3) | 21 (97.6) | 8 (100) | ||
| All Gram positiveb (225 isolates) | |||||||||||||
| Gepotidacin | 12 (5.3) | 15 (12.0) | 16 (19.1) | 12 (24.4) | 14 (30.7) | 22 (40.4) | 69 (71.1) | 43 (90.2) | 10 (94.7) | 3 (96.0) | 2 (96.9) | 2 (97.8) | 5 (100) |
| Ceftriaxone | 85 (37.8) | 19 (46.2) | 53 (69.8) | 68 (100) | |||||||||
| Clindamycin | 98 (43.6) | 7 (46.7) | 12 (52.0) | 32 (66.2) | 41 (84.4) | 35 (100) | |||||||
| Imipenem | 27 (12.0) | 22 (21.8) | 27 (33.8) | 14 (40.0) | 13 (45.8) | 17 (53.3) | 4 (55.1) | 13 (60.9) | 60 (87.6) | 28 (100) | |||
| Metronidazole | 70 (31.1) | 93 (72.4) | 41 (90.7) | 12 (96.0) | 5 (98.2) | 1 (98.7) | 3 (100) | ||||||
| Moxifloxacin | 6 (2.7) | 29 (15.6) | 20 (24.4) | 12 (29.8) | 69 (60.4) | 17 (68.0) | 17 (75.6) | 55 (100) | |||||
| Piperacillin-tazobactam | 36 (16.0) | 24 (26.7) | 23 (36.9) | 6 (39.6) | 5 (41.8) | 2 (42.7) | 10 (47.1) | 85 (84.9) | 15 (91.6) | 19 (100) | |||
Gram-negative isolates included Bacteroides caccae (n = 2), Bacteroides fragilis (n = 114), Bacteroides ovatus (n = 11), Bacteroides stercoris (n = 3), Bacteroides thetaiotaomicron (n = 48), Bacteroides uniformis (n = 4), Bacteroides vulgatus (n = 9), Bilophila wadsworthia (n = 26), Fusobacterium necrophorum (n = 3), Fusobacterium nucleatum (n = 17), Fusobacterium not identified at the species level (n = 5), Porphyromonas asaccharolytica (n = 9), Porphyromonas endodontalis (n = 2), Porphyromonas gingivalis (n = 2), Porphyromonas levii (n = 1), Porphyromonas somerae (n = 5), Porphyromonas not identified at the species level (n = 7), Prevotella bivia (n = 11), Prevotella buccae (n = 10), Prevotella denticola (n = 5), Prevotella disiens (n = 1), Prevotella melaninogenica (n = 3), Sutterella wadsworthensis (n = 10), Veillonella alcalescens (n = 1), Veillonella parvula (n = 9), and Veillonella not identified at the species level (n = 15).
Gram-positive isolates included Actinomyces europaeus (n = 2), Actinomyces georgiae (n = 1), Actinomyces israelii (n = 1), Actinomyces meyeri (n = 1), Actinomyces neuii (n = 3), Actinomyces odontolyticus (n = 3), Actinomyces radingae (n = 3), Actinomyces turicensis (n = 2), Actinomyces not identified at the species level (n = 6), Bifidobacterium adolescentis (n = 5), Bifidobacterium breve (n = 3), Bifidobacterium dentium (n = 4), Bifidobacterium longum (n = 7), Bifidobacterium pseudocatenulatum (n = 3), Bifidobacterium not identified at the species level (n = 4), Clostridioides difficile (n = 100), Collinsella aerofaciens (n = 5), Eggerthella lenta (n = 21), Eubacterium limosum (n = 2), Eubacterium nodatum (n = 1), Eubacterium not identified at the species level (n = 23), and Peptostreptococcus anaerobius (n = 25).