Table 3.
Association of LAEDVI and LAESVI with HF Hospitalization
| LAEDVI | LAESVI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile IV vs. I | Per 1 ml/m2 Increase | Quartile IV vs. I | Per 1 ml/m2 Increase | ||||||
| HR (95% CI) |
p-value | HR (95% CI) |
p-value | HR (95% CI) |
p-value | HR (95% CI) |
p-value | ||
| Unadjusted | 5.96 (3.45-10.23) | <0.001 | 1.05 (1.03-1.07) | <0.001 | 4.85 (2.84-8.37) | <0.001 | 1.04 (1.03-1.06) | <0.001 | |
| Model 1 | 5.11 (2.93-8.92) | <0.001 | 1.05 (1.03-1.07) | <0.001 | 4.21 (2.44-7.30) | <0.001 | 1.04 (1.03-1.06) | <0.001 | |
| Model 2 | 3.44 (1.83-6.46) | <0.001 | 1.03 (1.01-1.05) | <0.001 | 3.09 (1.66-5.78) | <0.001 | 1.03 (1.00-1.04) | <0.001 | |
| Model 3 | 3.76 (1.84-7.71) | <0.001 | 1.03 (1.00-1.05) | =0.02 | 2.74 (1.37-5.47) | <0.001 | 1.02 (1.00-1.04) | <0.001 | |
| Model 4 | 3.20 (1.53-6.69) | =0.002 | 1.02 (1.00-1.04) | =0.11 | 2.73 (1.33-5.62) | =0.002 | 1.02 (1.00-1.04) | =0.05 | |
| Model 5 | 2.07 (0.91-4.68) | =0.08 | 1.05 (1.01-1.09) | <0.001 | 2.14 (0.98-4.65) | =0.08 | 1.03 (1.00-1.05) | =0.02 | |
Model 1 – age, sex, race
Model 2 – Model 1 plus CV risk factors (prior revascularization or heart failure), medications (beta blockers, angiotensin inhibitors, diuretics, and antiarrhythmic drugs), systolic blood pressure, heart rate, and basic labs (LDL and eGFR)
Model 3 – Model 2 plus inducible ischemia
Model 4 – Model 3 plus N-terminal pro–B-type natriuretic peptide
Model 5 – Model 4 plus echocardiographic parameters (left ventricular end-diastolic and end-systolic volume indices, pseudonormal or restrictive left ventricular diastolic function, left ventricular ejection fraction, and left ventricular mass index)