Table 4.
Association of LAEDVI and LAESVI with the Composite CV Outcome (HF hospitalization, MI, stroke, heart disease death)
| LAEDVI | LAESVI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile IV vs. I | Per 1 ml/m2 Increase | Quartile IV vs. I | Per 1 ml/m2 Increase | ||||||
| HR (95% CI) |
p-value | HR (95% CI) |
p-value | HR (95% CI) |
p-value | HR (95% CI) |
p-value | ||
| Unadjusted | 2.97 (2.07-4.22) | <0.001 | 1.04 (1.03-1.05) | <0.001 | 2.17 (1.56-3.07) | <0.001 | 1.03 (1.02-1.04) | <0.001 | |
| Model 1 | 2.71 (1.89-3.89) | <0.001 | 1.04 (1.03-1.05) | <0.001 | 1.95 (1.38-2.77) | <0.001 | 1.03 (1.02-1.04) | <0.001 | |
| Model 2 | 2.15 (1.41-3.28) | <0.001 | 1.02 (1.01-1.03) | <0.001 | 1.75 (1.16-2.65) | =0.01 | 1.02 (1.00-1.03) | <0.001 | |
| Model 3 | 2.04 (1.29-3.22) | =0.002 | 1.02 (1.01-1.03) | <0.001 | 1.50 (0.96-2.34) | =0.07 | 1.01 (1.00-1.03) | =0.02 | |
| Model 4 | 1.73 (1.07-2.80) | =0.03 | 1.01 (1.00-1.03) | =0.10 | 1.42 (0.89-2.27) | =0.14 | 1.00 (1.00-1.02) | =0.42 | |
| Model 5 | 1.33 (0.79-2.25) | =0.28 | 1.01 (1.03-1.04) | =0.21 | 1.23 (0.75-2.02) | =0.42 | 1.00 (0.99-1.02) | =0.75 | |
Model 1 – age, sex, race
Model 2 – Model 1 plus CV risk factors (prior revascularization or heart failure), medications (beta blockers, angiotensin inhibitors, diuretics, and antiarrhythmic drugs), systolic blood pressure, heart rate, and basic labs (LDL and eGFR)
Model 3 – Model 2 plus inducible ischemia
Model 4 – Model 3 plus N-terminal pro–B-type natriuretic peptide
Model 5 – Model 4 plus echocardiographic parameters (left ventricular end-diastolic and end-systolic volume indices, pseudonormal or restrictive left ventricular diastolic function, left ventricular ejection fraction, and left ventricular mass index)