Table 5.
Association of LAEDVI and LAESVI with All-Cause Mortality
| LAEDVI | LAESVI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile IV vs. I | Per 1 ml/m2 Increase | Quartile IV vs. I | Per 1 ml/m2 Increase | ||||||
| HR (95% CI) |
p-value | HR (95% CI) |
p-value | HR (95% CI) |
p-value | HR (95% CI) |
p-value | ||
| Unadjusted | 2.08 (1.54-2.83) | <0.001 | 1.03 (1.02-1.04) | <0.001 | 1.90 (1.41-2.58) | <0.001 | 1.02 (1.01-1.03) | <0.001 | |
| Model 1 | 1.86 (1.36-2.54) | <0.001 | 1.02 (1.01-1.04) | <0.001 | 1.58 (1.16-2.16) | =0.004 | 1.02 (1.00-1.03) | <0.001 | |
| Model 2 | 1.71 (1.20-2.43) | =0.003 | 1.01 (1.00-1.03) | =0.01 | 1.60 (1.13-2.28) | =0.01 | 1.01 (1.00-1.02) | =0.02 | |
| Model 3 | 1.60 (1.08-2.36) | =0.02 | 1.01 (1.00-1.02) | =0.08 | 1.46 (1.01-2.15) | =0.05 | 1.00 (1.00-1.02) | =0.14 | |
| Model 4 | 1.42 (0.94-2.14) | =0.10 | 1.00 (1.00-1.02) | =0.58 | 1.36 (0.92-2.04) | =0.13 | 1.00 (1.00-1.01) | =0.64 | |
| Model 5 | 1.41 (0.91-2.21) | =0.13 | 1.01 (1.00-1.03) | =0.27 | 1.32 (0.87-2.01) | =0.20 | 1.00 (0.99-1.02) | =0.53 | |
Model 1 – age, sex, race
Model 2 – Model 1 plus CV risk factors (prior revascularization or heart failure), medications (beta blockers, angiotensin inhibitors, diuretics, and antiarrhythmic drugs), systolic blood pressure, heart rate, and basic labs (LDL and eGFR)
Model 3 – Model 2 plus inducible ischemia
Model 4 – Model 3 plus N-terminal pro–B-type natriuretic peptide
Model 5 – Model 4 plus echocardiographic parameters (left ventricular end-diastolic and end-systolic volume indices, pseudonormal or restrictive left ventricular diastolic function, left ventricular ejection fraction, and left ventricular mass index)