TABLE 1.
Demographic and clinical characteristics of patientsa
| Variable name | Group MFX+RIF (n = 31) | Group MFX (n = 20) | Statistical test resultsb |
|---|---|---|---|
| Male sex, n (%) | 24 (77) | 14 (70) | P = 0.599 |
| Age, median (IQR) | 34 (24–52) | 37 (25–43) | P = 0.656 |
| Born in a foreign country, n (%) | 28 (90) | 16 (80) | P = 0.416 |
| Body weight in kgc, median (IQR) | 61.6 (52.1–71.2) | 63.9 (55.1–76.7) | P = 0.569 |
| Body mass index (BMI)c, median (IQR) | 22.0 (18.1–24.3) | 21.0 (19.0–23.2) | P = 0.883 |
| PG-SGA (malnutrition) score ≥ 9 n (%) | 12 (75) | 4 (44) | P = 0.200 |
| Localization of disease, n (%) | P = 0.407 | ||
| Pulmonary TB | 21 (67) | 10 (50) | |
| Extrapulmonary TB | 6 (19) | 7 (35) | |
| Pulmonary + extrapulmonary TB | 4 (13) | 3 (15) | |
| Previously treated for TB, n (%) | 4 (13) | 3 (15) | P = 1.00 |
| Co-infections, n (%) | |||
| HIV | 0 (0) | 2 (10) | |
| Hepatitis B | 1 (3) | 1 (5) | |
| Hepatitis C | 1 (3) | 1 (5) | |
| Comorbidities, n (%) | |||
| Diabetes | 8 (26) | 3 (15) | P = 0.489 |
| Mental health condition/ symptomsd | 6 (19) | 3 (15) | P = 0.724 |
| Intermittent hemodialysis | 1 (3) | 0 (0) | NA |
| Risk factors, n (%) | |||
| Smoking history | 14 (45) | 10 (50) | P = 0.817 |
| Alcohol abuse | 3 (10) | 0 (0) | NA |
| IV drug use | 0 (0) | 1 (5) | NA |
Patients who had blood sampled while on 400 mg/day moxifloxacin (Group MFX+RIF and Group MFX) and 600 mg/day rifampicin (Group MFX+RIF). Missing values: PG-SGA (Malnutrition Score), 15 (48.4%) of Group MFX+RIF and 11 (55.0%) of Group MFX. PG-SGA: Patient-Generated Subjective Global Assessment, a score of 9 or above indicates a critical need for a nutritional intervention.
Results of Mann-Whitney U test for continuous variables and Chi-Square or Fisher’s Exact test for categorical variables.
Weight and BMI at time of blood sampling.
Also includes patients without an explicit diagnosis of mental illness but who received medication or psychological support as a result of mental health symptoms.