TABLE 1.

Cumulative MIC distribution of cefepime in the presence and absence of zidebactam, taniborbactam, and enmetazobactam in 400 carbapenemase-producing Enterobacterales strains

Isolate type	Cefepime/BLIs combinationsa	Cumulative % of isolates at MIC (mg/L)									% isolates with MICs values
		≤0.5	1	2	4	8	16	32	64	≥128	≤2 mg/L	≥16 mg/L
All isolates (n  =  400)
	Cefepime	5.5	12.3	15.0	18.8	20.5	25.5	38.3	52.5	100	15.0	79.5
	Cefepime/zidebactam	87.5	96.0	99.0	99.5	100					99.0	0
	Zidebactam	64.3	73.3	77.5	78.0	78.0	78.0	79.3	79.3	100	77.5	22.0
	Cefepime/taniborbactam	55.0	77.8	90.0	97.0	99.0	99.5	99.5	99.5	100	90.0	1.0
	Cefepime/enmetazobactam	36.0	50.3	61.8	67.8	72.5	79.3	83.5	86.5	100	61.8	27.5
All isolates
No producing ESBLs (n  =  106)	Cefepime	15.1	34.9	41.5	47.2	49.1	53.8	59.4	66.0	100	41.5	50.9
	Cefepime/zidebactam	76.4	95.3	100							100	0
	Zidebactam	63.2	78.3	84.9	84.9	84.9	84.9	85.8	85.8	100	84.9	15.1
	Cefepime/taniborbactam	51.9	73.6	88.7	96.2	99.1	100				88.7	0.9
	Cefepime/enmetazobactam	34.9	44.3	50.9	53.8	56.6	62.3	65.1	69.8	100	50.9	43.4
Producing ESBLs (n  =  294)	Cefepime	2.0	4.1	5.4	8.5	10.2	15.3	30.6	47.6	100	5.4	89.8
	Cefepime/zidebactam	91.5	96.3	98.6	99.3	100					98.6	0
	Zidebactam	64.6	71.4	74.8	75.5	75.5	75.5	76.9	76.9	100	74.8	24.5
	Cefepime/taniborbactam	56.1	79.3	90.5	97.3	99.0	99.3	99.3	99.3	100	90.5	1.0
	Cefepime/enmetazobactam	36.4	52.4	65.6	72.8	78.2	85.4	90.1	92.5	100	65.6	21.8

^aTaniborbactam and enmetazobactam did not show antimicrobial activity, displaying MICs ≥256 mg/L for all isolates.