TABLE 3.
Bacterial species, sequence type, and susceptibility to cefepime of clinical Enterobacterales showing high MIC values for cefepime/taniborbactam (MIC ≥16mg/L)a
| Genome no. | Species | ST | MIC (mg/L) |
Carbapenemase | Other β-lactamases |
Porins | PBPs | Transcription regulators AcrAB-TolC | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Cefepime | Cefepime/ taniborbactam | ESBL β-lactamases | Non- ESBL β-lactamases | |||||||
| AI2843 | E. coli | 410 | ≥128 | 16 | NDM-5 | CTX-M-15 | EC-like, (2x)TEM-1, (2x)OXA-1, CMY-2 | PBP3 (I532L, Y334_N337insYRIN) | ||
| AI2858 | E. coli | 648 | ≥128 | ≥128 | NDM-7 | CTX-M-15 | EC-like, CMY-6, OXA-1 | PBP2 (V522I) PBP3 (I532L, Y334_N337insYRIN) |
||
| AI2867 | K. pneumoniae | 39 | ≥128 | ≥128 | VIM-1 | (2x)CTX-M-15 | (2x)OXA-1, SHV-11 | OmpK35 NF (W316*) | ||
| AI2992 | E. cloacae complex | 96 | 16 | 16 | IMP-8 | MIR-like, OXA-101 | ||||
a
(2x), the strain has two copies of the gene coding for the specified β-lactamase; NF, nonfunctional; asterisk (*), premature stop codon.