TABLE 1.
Clinical and demographic characteristics of patients with BSI episodes presenting with and without septic shockc
| Characteristic | All episodes (n = 1,563) | No septic shock (n = 1,306) | Septic shock (n = 257) | P value |
|---|---|---|---|---|
| Demographic data | ||||
| Age, median (IQR), yr | 59 (48–67) | 61 (51–69) | 59 (47–66) | 0.616 |
| Male sex | 918 (59) | 768 (59) | 150 (58) | 0.896 |
| Underlying disease | ||||
| Hematological malignancy | 1,348 (86) | 1,168 (89) | 180 (70) | <0.001 |
| Solid neoplasma | 238 (15) | 157 (12) | 81 (32) | <0.001 |
| Hematopoietic stem cell transplant | 400 (26) | 355 (27) | 45 (18) | 0.001 |
| Allogenic/autologous | 249/151 (62/38)b | 215/140 (61/39)b | 34/11 (76/24)b | 0.051 |
| Any comorbidity | 456 (29) | 366 (28) | 90 (35) | 0.024 |
| Corticosteroid therapy | 588 (38) | 461 (35) | 127 (49) | <0.001 |
| Nosocomial BSI (vs health care or community acquired) | 999 (64) | 883 (68) | 116 (45) | <0.001 |
| Source of BSI | ||||
| Endogenous/unknown | 763 (49) | 650 (50) | 113 (44) | 0.089 |
| Catheter related | 333 (21) | 309 (24) | 24 (9) | <0.001 |
| Abdominal | 102 (7) | 72 (6) | 30 (12) | <0.001 |
| Pulmonary | 97 (6) | 49 (4) | 48 (19) | <0.001 |
| Urinary | 83 (5) | 62 (5) | 21 (8) | 0.025 |
| Inappropriate empirical antibiotic therapy | 471 (30) | 426 (32.6) | 45 (17.5) | <0.001 |
| For Gram-positive cocci | 290 (18.6) | 277 (21.2) | 13 (5.1) | <0.001 |
| For Gram-negative bacilli | 146 (9.3) | 121 (9.3) | 25 (9.7) | 0.816 |
| Outcome | ||||
| Mechanical ventilation requirement | 100 (6.6) | 29 (2.3) | 71 (27.6) | <0.001 |
| 30-day mortality | 342 (21.9) | 201 (15.4) | 141 (54.9) | <0.001 |
a
There were 25 patients who had both a hematological malignancy and a solid neoplasm.
b
Percentage among hematopoietic stem cell transplant recipients.
c
Abbreviations: IQR, interquartile range; BSI, bloodstream infection. All values except age are shown as no. (%).