TABLE 5.
In vitro potencies of additional oral beta-lactams in combination with QPX7728 at 4 μg/mL or comparator combinations against beta-lactamase-producing strains of Enterobacterales according to beta-lactamase
| Group and MIC parameter | Value (μg/mL) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amdinocillin | Amdinocillin + QPX7728 | Cefaclor | Cefaclor + QPX7728 | Cefuroxime | Cefuroxime + QPX7728 | Cephalexin | Cephalexin + QPX7728 | Meropenem | Meropenem + QPX7728 | Ceftazidime | Ceftazidime + avibactam | |
| All (n = 230) | ||||||||||||
| MIC50 | >64 | 1 | >64 | 4 | >64 | 32 | >64 | 32 | 4 | ≤0.06 | >64 | 1 |
| MIC90 | >64 | >64 | >64 | 64 | >64 | >64 | >64 | >64 | >64 | 0.25 | >64 | >64 |
| Range | 0.5 to >64 | 0.125 to >64 | 2 to >64 | ≤0.06 to >64 | 8 to >64 | 0.5 to >64 | 16 to >64 | 1 to >64 | ≤0.06 to >64 | ≤0.06 to 4 | 0.25 to >64 | ≤0.06 to >64 |
| ESBL (n = 84)a | ||||||||||||
| MIC50 | >64 | 1 | >64 | 2 | >64 | 8 | >64 | 8 | ≤0.06 | ≤0.06 | 64 | 0.5 |
| MIC90 | >64 | 8 | >64 | 16 | >64 | 64 | >64 | >64 | 4 | 0.25 | >64 | 4 |
| Range | 0.5 to >64 | 0.125 to >64 | 2 to >64 | ≤0.06 to >64 | 8 to >64 | 0.5 to >64 | 16 to >64 | 1 to >64 | ≤0.06 to 16 | ≤0.06 to 0.5 | 0.25 to >64 | ≤0.06 to 64 |
| Plasmidic class C (n = 12)b | ||||||||||||
| MIC50 | >64 | 1 | >64 | 2 | >64 | 32 | >64 | 32 | ≤0.06 | ≤0.06 | >64 | 0.5 |
| MIC90 | >64 | >64 | >64 | 32 | >64 | >64 | >64 | >64 | 2 | 0.125 | >64 | 4 |
| Range | 0.5 to >64 | 0.5 to >64 | >64 | 1 to 32 | 32 to >64 | 8 to >64 | >64 | 8 to >64 | ≤0.06 to 4 | ≤0.06 to 0.5 | 2 to >64 | 0.25 to 16 |
| KPC (n = 48)c | ||||||||||||
| MIC50 | >64 | 2 | >64 | 8 | >64 | 32 | >64 | 32 | 16 | ≤0.06 | >64 | 2 |
| MIC90 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | 1 | >64 | 8 |
| Range | >64 | 0.25 to >64 | 64 to >64 | 0.25 to >64 | 8 to >64 | 1 to >64 | 64 to >64 | 2 to >64 | 0.5 to >64 | ≤0.06 to 4 | 0.5 to >64 | 0.125 to >64 |
| OXA-48 (n = 48) | ||||||||||||
| MIC50 | >64 | 1 | >64 | 8 | >64 | 32 | >64 | 32 | 16 | 0.125 | >64 | 2 |
| MIC90 | >64 | 16 | >64 | >64 | >64 | >64 | >64 | >64 | 64 | 0.25 | >64 | 4 |
| Range | 0.5 to >64 | 0.25 to >64 | >64 | 0.5 to >64 | 32 to >64 | 1 to >64 | >64 | 2 to >64 | ≤0.06 to 64 | ≤0.06 to 0.25 | 0.5 to >64 | 0.25 to 64 |
| MBL (n = 36) | ||||||||||||
| MIC50 | >64 | 1 | >64 | 16 | >64 | >64 | >64 | 64 | 16 | ≤0.06 | >64 | >64 |
| MIC90 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | 0.125 | >64 | >64 |
| Range | 0.5 to >64 | 0.25 to >64 | 2 to >64 | 0.25 to >64 | 8 to >64 | 0.5 to >64 | 16 to >64 | 2 to >64 | ≤0.06 to >64 | ≤0.06 to 2 | 2 to >64 | ≤0.06 to >64 |
a
ESBL, no coproduced carbapenemases or plasmidic class C enzymes.
b
Plasmidic class C, no carbapenemases.
c
Many carbapenemase-producing strains also coproduced ESBLs or class C beta-lactamases.