FIG 9.
Simulated exposure-response profiles of the recommended and once-daily bedaquiline dosages during 8 weeks of treatment. PK-PD model simulations were performed for a population-typical individual of the time-average bedaquiline (BDQ) plasma concentrations, solid-culture log10 CFU per milliliter of sputum, and liquid culture time to positivity (TTP) for the recommended dose (REC) (400 mg once daily for 2 weeks followed by 200 mg three times per week) and 200 mg, 300 mg, and 400 mg once daily.