TABLE 5.
Emax model parameters for population mean and median profiles generated from Monte Carlo PK-PD model simulations of the 14-day EBA for once-daily dosing with a range of 50 to 3,000 mga
| Population profile | Least-squares estimate for EBA0–14 (SE) using: |
|||
|---|---|---|---|---|
| CFU |
TTP |
|||
| Emax (log10 CFU/mL/day) | D50 (mg) | Emax (h/day) | D50 (mg) | |
| Mean | 0.18 (0.0007) | 280 (4) | 10 (0.04) | 290 (5) |
| Median | 0.16 (0.001) | 320 (8) | 8.2 (0.1) | 330 (8) |
a
The MC sample size was 10,000. EBA0–14, day 0 to day 14 EBA calculated with CFU counts or time to positivity (TTP); Emax, maximum EBA; D50, half-maximum effective dose.