Fig 4. siRNA targeting PRKACA transcript decreases expression of both transcript variants of LINC00473 in A9 clone.

(a) siRNA directed at PRKACA effectively decreases both PRKACA and DP protein levels following 48 and 72 hours of treatment. Full-length blots are presented in S1 Fig. (b-c) Treatment with PRKACA-siRNA demonstrates statistically significant decrease in LINC00473 TV1 and TV2 transcript levels at 48 and 72 hours. (*-p<0.005; **-p<0.05).