Table 3. Candidate genes within QTL regions.
Prioritized candidates shown for selected QTL. Candidates were prioritized by filtering on (1) differential expression during Mtb infection, and (2) variants within TB-expressed genes that segregated between informative CC haplotypes. Genes listed below contain non-synonymous variants (i.e. amino acid changes, regulatory mutations or splicing mutations) consistent with the identified singly causal haplotype (NOD for Tip5; CAST for Tip8). Hip42 displayed a more complex haplotype pattern (WSB/NOD vs AJ/B6/NZO), and candidate selection is discussed in the main text. Genes with missense or nonsense variants (denoted by *).
| Tip5 | Tip8 | Hip42 | |
|---|---|---|---|
| Ctsz | Fxyd5* | Siglecg | Ank3 |
| Tubb1 | Fxyd1 | Nkg7 | Cdk1 |
| Atp5e | Lgi4 | Cd33* | Tmem26 |
| Prelid3b | Fxyd3 | Siglece* | Slc16a9 |
| Zfp831* | Hpn | Klk13 | Fam13c |
| Edn3 | Scn1b | Klk8 | Rhobtb1 |
| Gm14391* | Gramd1a* | Klk7* | |
| Gm6710 | Pdcd2l* | Klk1b9* | |
| Zfp931 | Gpi1 | Klk1 | |
| 4931406P16Rik | Clec11a | ||
| Kctd15 | Shank1 | ||
| Chst8 | Syt3 | ||
| Pepd | Lrrc4b | ||
| Cebpa | Josd2 | ||
| Slc7a10 | Spib | ||
| Lrp3* | Pold1 | ||
| Rhpn2 | Napsa* | ||
| Faap24 | Kcnc3 | ||
| Tdrd12* | Myh14 | ||
| Ankrd27* | Atf5 | ||
| Pdcd5 | Il4i1 | ||
| Dpy19l3 | Pnkp* | ||
| Tshz3* | Ptov1 | ||
| Ccne1 | Fuz | ||
| 1600014C10Rik | Tsks | ||
| Plekhf1 | Cpt1c* | ||
| Vstm2b | |||
| Zfp975* | |||
| Zfp715* |